plasminogen activator inhibitor-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4254	TM5441		PAI-1 , Apoptosis
	TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).		PAI-1 , Apoptosis
T8962	TM5007		PAI-1
	TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 of 29 uM).		PAI-1
T3442	UK-371804	UK371804	PAI-1 , Serine Protease
	UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.		PAI-1 , Serine Protease
T13408	ZK824190		Others , Serine Protease
	ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).		Others , Serine Protease
T13257	Upamostat		PAI-1 , Serine/threonin kinase , Serine Protease
	Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.		PAI-1 , Serine/threonin kinase , Serine Protease
T4255	TM5275 sodium	TM5275 sodium salt	PAI-1
	TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).		PAI-1
T2030	Tiplaxtinin	PAI-039,Tiplasinin	PAI-1 , Apoptosis
	Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.		PAI-1 , Apoptosis
T4S0592	Toddalolactone	(+)-Toddalolactone	PAI-1
	Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.		PAI-1
T3876	Loureirin B		PAI-1 , ERK , Potassium Channel , JNK
	Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathw...		PAI-1 , ERK , Potassium Channel , JNK
T29856	Aleplasinin	PAZ 417,PAZ417,PAZ-417	PAI-1
	Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic system. Aleplasinin can be used in Alzheimer's disease studies...		PAI-1
T28788	SK-216	SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor
	SK-216 is a specific PAI-1 inhibitor. SK-216 reduced the extent of angiogenesis in the tumors and inhibited VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro. SK-216 reduced the...
T60248	4-Aminobenzamidine dihydrochloride	p-Aminobenzamidine dihydrochloride	Serine Protease
	4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uPA) (K i =82 μM). 4-Aminobenzamidine can inh...		Serine Protease
T13251	UKI-1	UKI-1C	Others
	UKI-1 is a urokinase-type plasminogen activator system synthetic inhibitor.		Others
T68572	IMD-1622
	IMD-1622 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor.
T70417	XR 1853
	XR 1853 is a low molecular weight modulator of human plasminogen activator inhibitor-1 activity.
T25915	Diaplasinin	PAI-749,PAI749,PAI 749
	PAI-749 is a selective and effective antagonist agent of plasminogen activator inhibitor 1 (PAI-1).
T70810	THR-18
	THR-18 is an 18-mer peptide derived from the sequence of human plasminogen activator inhibitor 1 (PAI-1), having the ability to bind to a site of tissue plasminogen activator (tPA) distal to its catalytic site and uncoup...
T35931	GGACK (hydrochloride)
	GGACK is an inhibitor of urokinase-type plasminogen activator (uPA) and factor Xa (Kis = 1.8 and 8.7 μM, respectively).1,2 1.Kettner, C., and Shaw, E.The susceptibility of urokinase to affinity labeling by peptides of ar...
T78015	LCKLSL hydrochloride
	LCKLSL hydrochloride, an N-terminal hexapeptide and competitive annexin A2 (AnxA2) inhibitor, effectively disrupts the interaction between tissue plasminogen activator (tPA) and AnxA2. It additionally hinders plasmin gen...